If any of the above applies to you, talk to your doctor before you start taking this medicine. You must stop taking Metformin for a certain period of time before and after the examination or the surgery.
Your doctor will decide whether you need any other treatment for this time. The risk of lactic acidosis is also increased with uncontrolled diabetes, prolonged fasting or alcohol intake. Symptoms of lactic acidosis are vomiting, bellyache abdominal pain with muscle cramps, a general feeling of not being well with severe tiredness, and difficulty breathing.
The metformin pKa values make metformin a stronger base than most other basic medications with less than 0. Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value log 10 of the distribution coefficient of the nonionized form between octanol and water of These chemical parameters indicate low lipophilicity and, consequently, rapid passive diffusion of metformin through cell membranes is unlikely.
As a result of its low lipid solubility it requires the transporter SLC22A1 in order for it to enter cells. More lipophilic derivatives of metformin are presently under investigation with the aim of producing prodrugs with superior oral absorption than metformin. It is cleared from the body by tubular secretion and excreted unchanged in the urine; metformin is undetectable in blood plasma within 24 hours of a single oral dose.
In , metformin, unlike some other similar compounds, was found not to decrease blood pressure and heart rate in animals. Garcia  used metformin he named it Fluamine to treat influenza; he noted the medication "lowered the blood sugar to minimum physiological limit" and was not toxic. Garcia believed metformin to have bacteriostatic , antiviral , antimalarial , antipyretic and analgesic actions.
Metformin Hydrochloride mg is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take Metformin Hydrochloride mg by mouth as directed by your doctor, usually times a day with meals. Drink plenty of fluids while taking Metformin Hydrochloride mg unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking.
Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. To reduce your risk of side effects such as upset stomach , your doctor may direct you to start Metformin Hydrochloride mg at a low dose and gradually increase your dose. Take Metformin Hydrochloride mg regularly in order to get the most benefit from it.
Remember to use Metformin Hydrochloride mg at the same times each day. Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in the mouth may occur. Low blood sugar may occur if this drug is prescribed with other diabetes medications.
Talk with your doctor or pharmacist about whether the dose of your other diabetes medication s needs to be lowered.
It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction right away.
If you do not have a dose-measuring device, ask your pharmacist for one. Some tablet forms of metformin are made with a shell that is not absorbed or melted in the body.
Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medication less effective. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar hypoglycemia can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
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